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TMP-153
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产品介绍
产品介绍
产品信息
商品描述
TMP-153, a potent SOAT (acyl-CoA:cholesterol acyltransferase (ACAT)) inhibitor, has been shown to inhibit cholesterol esterification and reduce its influx into the plasma. In murine liver experiments, this compound has been reported to significantly reduce unesterified cholesterol content in addition to reducing the content of esterified cholesterol. Other studies have noted that TMP-153 is toxic to prion-infected neuronal (ScGT1) cells. ACAT inhibitors have demonstrated the ability to increase caspase-3 activity and prostaglandin E2 production in ScGT1 cells.
分子量
437.9
纯度
≥98%
可溶性
Soluble in DMSO (>25 mg/mL) and ethanol (10 mg/mL with warming)
IC50
cholesterol acyltransferase (ACAT): IC50 = 5-10 nM; Acyl coenzyme A:cholesterol acyltransferase 1: IC50 = 5.8 nM (Rattus norvegicus)
应用
实验应用
A selective and potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
背景
分子式
C24H18ClF2N3O
CAS号
128831-46-9
沸点
489.03° C at 760 mmHg
PK值
pKa: 11.70, pKb: 4.40
密度
1.39 g/cm3
折射率
n20D 1.69
制备和贮存
保存方式
Store at room temperature
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