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Val77-Leu233
17 kDa(Reducing)
Tumor necrosis factor alpha (TNFa) is a multifunctional proinflammatory cytokine synthesized mainly by nucleated blood
cells as a 233 aa type II transmembrane protein which is cleaved by ADAM17 between aa 76-77 to form a soluble
homotrimeric complex. TNFa plays a role in lipid metabolism, coagulation, and endothelial function and has been
associated with cancer, infection and inflammation (including inflammatory bowel disease), ischemia/reperfusion injury
and heart failure, and insulin resistance.
Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
参考图片
EC50 < 0.1ng/ml, measured in a cytotoxicity assay using L-929.
Immobilized TNF-α, Human (Cat. No. UA040005) at 10μg/ml (100μl/well) can bind TNFR-1/CD120a His Tag, Human (Cat. No. UA040028) with EC50 of 0.167 μg/ml.
Anti-His antibody Immobilized on CM5 Chip captured TNFR-1/CD120a His Tag, Human (Cat. No. UA040028), can bind TNF-α, Human (Cat. No. UA040005) with an affinity constant of 0.106nM as determined in SPR assay.
TNF-α, Human，2μg on SDS-PAGE under Non-reducing and reducing condition. The purity is greater than 95%.
Anti-His antibody Immobilized on CM5 Chip captured TNFR-2/CD120b His Tag, Human (Cat. No. UA010138), can bind TNF-α, Human (Cat. No. UA040005) with an affinity constant of 1.53 nM as determined in SPR assay.