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Alexa Fluor 700 Mouse Anti-Human TNF(MAb11)
品牌： BD Pharmingen
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对比
咨询反应种属：
Human (QC Testing), Rhesus, Cynomolgus, Baboon (Tested in Development)
来源宿主：
Mouse IgG1, κ
产品介绍
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产品信息
荧光素标记
抗原名称
TNF
宿主
Mouse IgG1, κ
商品描述
The MAb11 monoclonal antibody specifically binds to human tumor necrosis factor (TNF, also known as TNF-α) protein. TNF is an efficient juxtacrine, paracrine and endocrine mediator of inflammatory and immune functions. It regulates the growth and differentiation of a variety of cell types. TNF is cytotoxic for transformed cells when in conjunction with IFN-γ. It is secreted by activated monocytes/macrophages and other cells such as B cells, T cells and fibroblasts. The immunogen used to generate the MAb11 hybridoma was recombinant human TNF. The MAb11 antibody has been reported to crossreact with Rhesus Macaque TNF.
应用
反应种属
Human (QC Testing), Rhesus, Cynomolgus, Baboon (Tested in Development)
背景
别名
Tumor necrosis factor alpha; TNF-a; TNF-α; TNFSF2; Cachectin
制备和贮存
保存方式
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
参考图片
Expression of TNF by stimulated human peripheral blood lymphocytes. Human peripheral blood mononuclear cells were stimulated for 4 hrs with PMA (5 ng/ml, Sigma, Cat. No. P-8139) and Ionomycin (500 ng, Sigma, P-8139) in the presence of GolgiStop (Cat. No. 554715). Cells were harvested, fixed, permeabilized and stained with Alexa Fluor® 700 Mouse Anti-Human TNF (Cat. No. 557996). Dot plots were derived from gated events with the forward and side light scatter characteristics of lymphocytes. The quadrant markers for the bivariate dot plots were set based on the autofluorescence and isotype controls.
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