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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
4-1BBCD137TNFRSF9
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln128 of human 4-1BB/CD137/TNFRSF9 protein. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
分子量
32, 40
研究领域
癌症,免疫学和肿瘤学,
应用
反应种属
Human
目标/特异性
Specificity/Sensitivity
4-1BB/CD137/TNFRSF9 Antibody recognizes endogenous levels of total 4-1BB/CD137/TNFRSF9 protein.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).
1.Sun, Y. et al. (2002) Nat Med 8, 1405-13.
2.Wilcox, R.A. et al. (2002) J Clin Invest 109, 651-9.
3.Lin, W. et al. (2008) Blood 112, 699-707.
4.Wilcox, R.A. et al. (2002) J Immunol 168, 4262-7.
5.Melero, I. et al. (1997) Nat Med 3, 682-5.
6.Yonezawa, A. et al. (2015) Clin Cancer Res 21, 3113-20.
研究领域
癌症,免疫学和肿瘤学,
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
3604
UniProt ID
Q07011
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