TNIK Antibody

TRAF2 and NCK-interacting protein kinase (TNIK) is a member of the germinal center kinase (GCK) family (1). TNIK phosphorylates TCF4 and is an essential activator for Wnt signaling (2). Animal knockout model and kinase inhibition studies have reported that TNIK can stimulate both cancer cell growth and epithelial-mesenchymal transition (EMT) (3-5). TNIK has also been shown to promote F-actin disruption through its interactions with Rap2 (6). In neuronal cells, TNIK is enriched in the postsynaptic density (PSD), where it is reported to modulate neuronal receptor surface expression and dendrite complexity and signaling (7-9). 1.Fu, C.A. et al. (1999) J Biol Chem 274, 30729-37. 2.Mahmoudi, T. et al. (2009) EMBO J 28, 3329-40. 3.Masuda, M. et al. (2016) Nat Commun 7, 12586. 4.Kim, J. et al. (2014) PLoS One 9, e110180. 5.Shitashige, M. et al. (2010) Cancer Res 70, 5024-33. 6.Taira, K. et al. (2004) J Biol Chem 279, 49488-96. 7.Hussain, N.K. et al. (2010) J Neurosci 30, 14786-94. 8.Coba, M.P. et al. (2012) J Neurosci 32, 13987-99. 9.Larhammar, M. et al. (2017) J Neurosci 37, 11074-11084.