Toll-Like Receptor 12 Polyclonal Antibody

Rabbit

mouse TLR12 amino acids 911-926

The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules.1 The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.2 Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-1) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.WARNING This product is not for human or veterinary use.

For immunochemical analysis of TLR12

Antibodies/Primary Antibodies/Polyclonal Antibodies

Flow Cytometry,Western Blot

(+) Mouse TLR12 (+) Rat TLR12

Synonyms:TLR12

≥ 1 year

1.Srivastava, M.D., and Srivastava, B.I.S. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8⁺ NK/T cell line. Leukemia Research 7, 813-820 (2005).
2.Gibson, F.C.,Hong, C.,Chou, H.H., et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 109, 2801-2806 (2004).