TOX Alexa 647 NAN448B 100ug

TOX

Rat IgG1, κ

Recombinant Human TOX Protein

The NAN44B monoclonal antibody specifically binds to the thymocyte selection-associated protein high mobility group box protein, which is also known as TOX, TOX 1 and thymus high mobility group box protein. TOX belongs to the superfamily of transcription factors that contain the highly conserved high mobility group box (HMG-box) region, including a small subfamily of proteins (TOX2, TOX3 and TOX4) that share almost identical (HMG)-box sequences. TOX acts as a key regulator in the development of the adaptive immune system and is expressed by CD4+ helper T cells, CD8+cytotoxic T cells, regulatory T cells, NK cells, CD1D-dependent (NKT) cells and lymphoid tissue-inducer (LTi) cells. This DNA-binding factor regulates transcription by modifying chromatin structure and can reportedly serve as a critical regulator of T cell exhaustion and a potential immunotherapy target.

NAN448B The NAN44B monoclonal antibody specifically binds to the thymocyte selection-associated protein high mobility group box protein, which is also known as TOX, TOX 1 and thymus high mobility group box protein. TOX belongs to the superfamily of transcription factors that contain the highly conserved high mobility group box (HMG-box) region, including a small subfamily of proteins (TOX2, TOX3 and TOX4) that share almost identical (HMG)-box sequences. TOX acts as a key regulator in the development of the adaptive immune system and is expressed by CD4+ helper T cells, CD8+cytotoxic T cells, regulatory T cells, NK cells, CD1D-dependent (NKT) cells and lymphoid tissue-inducer (LTi) cells. This DNA-binding factor regulates transcription by modifying chromatin structure and can reportedly serve as a critical regulator of T cell exhaustion and a potential immunotherapy target.

Rat IgG1, κ

克隆 NAN448B (RUO)

0.2 mg/ml

Intracellular staining (flow cytometry) (Routinely Tested)

Human (QC Testing), Mouse (Tested in Development)

TOX

TOX; TOX 1; TOX1

Aqueous buffered solution containing ≤0.09% sodium azide.

研发参考(7) 1. Aliahmad P, de la Torre B, Kaye J. Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages.. Nat Immunol. 2010; 11(10):945-52. (Biology). 2. Jindal S, Pennock ND, Sun D, et al. Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes.. Nat Commun. 2021; 12(1):6341. (Clone-specific). 3. Liang C, Huang S, Zhao Y, Chen S, Li Y. TOX as a potential target for immunotherapy in lymphocytic malignancies.. Biomark Res. 2021; 9(1):20. (Biology). 4. Maestre L, García-García JF, Jiménez S, et al. High-mobility group box (TOX) antibody a useful tool for the identification of B and T cell subpopulations.. PLoS One. 2020; 15(2):e0229743. (Clone-specific: Flow cytometry). 5. Scott AC, Dündar F, Zumbo P, et al. TOX is a critical regulator of tumour-specific T cell differentiation.. Nature. 2019; 571(7764):270-274. (Biology). 6. Veldman J, Rodrigues Plaça J, Chong L, et al. CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2: Characterizing CD4+ T cells in Hodgkin lymphoma.. Oncoimmunology. 2022; 11(1):2033433. (Clone-specific). 7. Wilkinson B, Chen JY, Han P, Rufner KM, Goularte OD, Kaye J. TOX: an HMG box protein implicated in the regulation of thymocyte selection.. Nat Immunol. 2002; 3(3):272-80. (Biology).