TRAF1 (45D3) Rabbit mAb

TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses (1-3). Members of the TRAF family share a common carboxy-terminal "TRAF domain", which mediates interactions with associated proteins; many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified, TRAF1 and TRAF2, were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2 (TNFRII) (4). The six known TRAFs (TRAF1-6) act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation, and stress responses. 1.Arch, R.H. et al. (1998) Genes Dev 12, 2821-30. 2.Chung, J.Y. et al. (2002) J Cell Sci 115, 679-88. 3.Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-91. 4.Rothe, M. et al. (1994) Cell 78, 681-92.