TRDC/TCRdelta (E2E9T) Rabbit mAb

The γδ T Cell Receptor (TCR) is a heterodimer composed of a gamma chain and a delta chain expressed on the surface of T cells which participates in antigen recognition (1,2). Binding of gamma-delta TCR to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in CD3 chains of the antigen (3). Unlike αβ T cells, human γδ T cells recognize and kill transformed cells independently of human leukocyte antigen (HLA) restriction (3,4). γδ T lymphocytes develop largely in the thymus, generating their defining receptor via RAG-mediated rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes (3). In addition to the T cell receptor, γδ T cells usually also express activating natural killer (NK) receptors, which bind to stress-inducible surface molecules frequently expressed on malignant cells (4). 1.Brenner, M.B. et al. Nature 322, 145-9. 2.Davis, M.M. and Bjorkman, P.J. (1988) Nature 334, 395-402. 3.Vantourout, P. and Hayday, A. (2013) Nat Rev Immunol 13, 88-100. 4.Kabelitz, D. et al. (2020) Cell Mol Immunol 17, 925-939.