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Anti-TRPM8 (extracellular) Antibody
品牌： Alomone
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咨询纯度：
Affinity purified on immobilized antigen.
反应种属：
H, M, R
产品介绍
产品信息
纯化方式
Affinity purified on immobilized antigen.
宿主
兔
免疫原
Peptide SDVDGTTYDFAHC, corresponding to amino acid residues 917-929 of human TRPM8 (Accession Q7Z2W7). 3rd extracellular loop.
简单描述
A Rabbit Polyclonal Antibody to TRPM8 Channel
商品描述
Anti-TRPM8 (extracellular) Antibody (#ACC-049) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunoprecipitation, immunohistochemistry, immunocytochemistry, and neutralization applications. It has been designed to recognize TRPM8 from human, rat, and mouse samples.
同种型
Rabbit IgG.
纯度
Affinity purified on immobilized antigen.
形式
Lyophilized
组成成分
瞬时受体电位阳离子通道蛋白抗体;磷酸盐缓冲液;防腐剂(0.05%叠氮化钠溶液)
应用
实验应用
ICC, IF, IFC, IHC, IP, LCI, N, WB
反应种属
H, M, R
背景
别名
TRPP8, LTrpC6, Transient receptor potential cation channel subfamily M member 8
背景
The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named after the first member, melastatin (TRPM1), whose gene was identified in metastatic and benign melanomas.1 The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N-terminus and C-terminus. However, due to their long N-terminus and C-terminus they were also named the long TRP channel family.1
The TRPM family consists of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM7.1
The TRPM8 channel is the cold and menthol receptor activated by either cold temperatures(~28°C) or menthol.2
TRPM8 is expressed in dorsal root ganglia (DRGs) where about 5%-10% of the small diameter DRG neurons express the channel.3,4 In DRGs, TRPM8 expressing neurons do not express the TRPV1 channel.5 Overexpression of TRPM8 was found in prostate cancer cells. However, the physiological and pathological roles that these cells play is still elusive.6 In prostate, it was suggested that TRPM8 might play a possible role in the progression of cancer to the metastatic stage.6
The TRPM family consists of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM7.1
The TRPM8 channel is the cold and menthol receptor activated by either cold temperatures(~28°C) or menthol.2
TRPM8 is expressed in dorsal root ganglia (DRGs) where about 5%-10% of the small diameter DRG neurons express the channel.3,4 In DRGs, TRPM8 expressing neurons do not express the TRPV1 channel.5 Overexpression of TRPM8 was found in prostate cancer cells. However, the physiological and pathological roles that these cells play is still elusive.6 In prostate, it was suggested that TRPM8 might play a possible role in the progression of cancer to the metastatic stage.6
制备和贮存
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
研究资源识别码
AB_2040254.
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