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TSLPR Fc Chimera Protein, Human
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咨询55-72kDa (Reducing)
Gln23-Lys231 with Human IgG1 Fc at C-Terminus
55-72kDa (Reducing)
The TSLP receptor (TSLPR, also known as CRLM-2) is a heterodimeric cytokine receptor composed of a TSLP-binding subunit (TSLPRα) and the α-subunit of the IL-7 receptor (IL-7Rα). TSLPR mRNA is expressed in various immune cell types, including dendritic cells (DCs), T cells, B cells, mast cells, NKT cells, and monocytes, as well as in tissues such as the heart, skeletal muscle, kidney, and liver. While TSLPR has a low affinity for TSLP, it forms a high-affinity binding site for TSLP when combined with IL-7Rα, thereby initiating signaling. The TSLPR regulates target gene expression through the JAK/STAT signaling pathway, involving signal transducers and activators of transcription STAT3, STAT5, and STAT1. Genetic, experimental, and clinical evidence indicates that the TSLP-TSLPR pathway is implicated in the pathogenesis of allergic diseases, including atopic dermatitis (AD) and asthma.
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.L S Park. Cloning of the murine thymic stromallymphopoietin (TSLP) receptor: Formation of a functional heteromeric complexrequires interleukin 7 receptor. J Exp Med. 2000 Sep 4;192(5):659-70.