UBP 296 (10 mg)

11674376

Potent and selective kainate antagonist; selective for GluK1-containing receptors

333.3

(RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

Selective GluR5-subunit containing kainate receptor antagonist (apparent K_D = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Active enantiomer UBP 302 (Cat. No. 2079) available.

≥98% (HPLC)

Soluble to 10 mM in 1eq. NaOH with gentle warming and to 10 mM in DMSO

NC(CN1C=CC(=O)N(CC2=C(C=CC=C2)C(O)=O)C1=O)C(O)=O

C₁₅H₁₅N₃O₆

745055-86-1