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产品介绍
产品介绍
产品信息
商品描述
UBP 302 is a potent and selective GLUK5 (GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296. UBP 302 displays ~ 260-fold selectivity over AMPA receptors. UBP 296 displays ~ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors, has little or no action at NMDA or group I mGlu receptors and selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres.
分子量
333.30
纯度
≥98%
可溶性
Soluble to 25 mM in 1eq. NaOH and to 50 mM in DMSO
应用
实验应用
A potent and selective GLUK5 receptor antagonist
背景
别名
(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
分子式
C15H15N3O6
CAS号
745055-91-8
制备和贮存
保存方式
Store at -20° C
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