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产品介绍
产品介绍
产品信息
抗原名称
Omi/HtrA2 Protease
商品描述
UCF 101 is an inhibitor of Omi/HtrA2.
Omi/HtrA2, a mitochondria serine protease with close homology to bacterial HtrA chaperones, is released from the mitochondria in response to apoptotic stimuli. Omi/HtrA2 has been reported to be able to induce cell death via a mechanism involving its protease activity.
分子量
495.5
纯度
98%
可溶性
DMSO ：5 mg/ml
外观
light orange to dark orange powder
IC50
His-Omi134-458: IC50 = 9.5 µM; various other serine proteases: IC50 = ≥ 200 µM
In vitro(体外研究)
UCF 101 was identified in a HTS of a combinatorial library using Omi-(134-458) protease and fluorescein-casein as a generic substrate. UCF 101 exhibited specific activity against Omi/HtrA2 and very little activity against other serine proteases. UCF 101 showed a natural fluorescence that was used to monitor its ability to enter mammalian cells. In addition, when tested in caspase-9 (-/-) null fibroblasts, UCF 101 was able to inhibit Omi/HtrA2-induced cell death.
In vivo(体内研究)
In a previous study, rats were intraperitoneally administered UCF-101 at 1.5 micromol/kg 10 min prior to reperfusion. Results showed that UCF-101 treatment could significantly decrease cerebral infarct size by about 16.27% and also improve neurological behavior. Moreover, UCF-101 treatment was able to reduce TUNEL-positive cells in the cerebral cortex significantly. In addition, the upregulation in the expression of FasL and the cleavage products of active caspase-3 and caspase-8 induced by ischemia was attenuated in mice treated with UCF-101, while upregulation of FLIP levels was increased.
背景
别名
Omi/HtrA2 Protease Inhibitor
分子式
C27H17N3O5S
CAS号
313649-08-0
MDL
MFCD01000361
密度
~1.50 g/cm3 (Predicted)
折射率
n20D ~1.76 (Predicted)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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