UNC 3230 (10 mg)

46355372

Potent and selective PIP5K1C inhibitor; antinociceptive

344.43

5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide

Potent and selective PIP5K1C inhibitor (IC₅₀ = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP₂ levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.

≥99% (HPLC)

Soluble to 100 mM in DMSO

O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1

C₁₇H₂₀N₄O₂S

1031602-63-7