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Upadacitinib
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产品介绍
产品介绍
产品信息
抗原名称
JAK1；JAK2；JAK3；Tyk2
商品描述
Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM.
分子量
380.368
纯度
≥98%
可溶性
DMSO : ≥ 22 mg/mL (57.84 mM)
外观
White to light yellow solid
In vitro(体外研究)
In biochemical assays, Upadacitinib is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance).. The enhanced selectivity of Upadacitinib for JAK-1 over JAK-2 and JAK-3 may offer an improved benefit–risk profile in patients with RA range.
In vivo(体内研究)
Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) demonstrates efficacy in rat arthritis models.
背景
别名
乌帕替尼
分子式
C17H19F3N6O
CAS号
1310726-60-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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