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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human UQCRC2 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:50 - 1:250 |
| Immunoprecipitation | 1:50 |
同种型
Rabbit IgG
分子量
48
应用
目标/特异性
Specificity/Sensitivity
UQCRC2 (F8Y5N) Rabbit mAb recognizes endogenous levels of total UQCRC2 protein.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Ubiquinol-cytochrome c reductase complex core protein 2 (UQCRC2), also known as cytochrome b-c1 complex subunit 2, is a component of the ubiquinol-cytochrome c oxidoreductase complex (Complex III) in the mitochondrial electron transport chain (1,2). Studies show that AMPK increases UQCRC2 expression to promote mitophagy, protecting the liver against alcohol-induced injury (3). In addition, overexpression of UQCRC2 was shown to inhibit gastric cancer cell proliferation, invasion, and migration (4).
1.Zhou, Y. et al. (2022) Free Radic Biol Med 179, 301-316.
2.Burska, D. et al. (2021) Biochim Biophys Acta Mol Basis Dis 1867, 166147.
3.Lu, X. et al. (2021) Autophagy 17, 3622-3643.
4.Wang, D.W. et al. (2020) J Cancer 11, 5042-5055.
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
7385
UniProt ID
P22695
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