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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
UQCRFS1RISP
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro86 of human UQCRFS1/RISP protein. Antibodies are purified by peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
分子量
23
研究领域
癌症,细胞生物学,纤维化,代谢,神经科学
应用
反应种属
Human,Mouse,Rat,
目标/特异性
Specificity/Sensitivity
UQCRFS1/RISP Antibody recognizes endogenous levels of total UQCRFS1/RISP protein.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Ubiquinol-cytochrome c reductase iron-sulfur subunit (UQCRFS1), also known as Rieske iron-sulfur protein (RISP), is a component of Complex III in the mitochondrial electron transport chain. UQCRFS1/RISP and two other subunits, cytochrome b (MT-CYB) and cytochrome c1 (CYC1), are essential for the catalytic activity of Complex III (1). Studies show that UQCRFS1/RISP is required for fetal mouse hematopoietic stem cell differentiation and adult mouse hematopoietic stem cell quiescence (2). In addition, loss of UQCRFS1/RISP decreases the strength of T cell receptor (TCR) signaling, indicating that this protein is critical for optimal TCR signaling (3).
1.Maio, N. et al. (2017) Cell Metab 25, 945-953.e6.
2.Ansó, E. et al. (2017) Nat Cell Biol 19, 614-625.
3.Weng, X. et al. (2021) Proc Natl Acad Sci U S A 118, e2021385118. doi: 10.1073/pnas.2021385118.
研究领域
癌症,细胞生物学,纤维化,代谢,神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
7386
UniProt ID
P47985
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