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产品介绍
产品介绍
产品信息
抗原名称
Abl1 ,LRRK2 ,MLK3 ,MLK1 ,VEGFR1/FLT1
商品描述
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.
分子量
421.54
纯度
98%
可溶性
Ethanol ；6 mg/mL (14.2 mM)
DMSO ：75 mg/mL (177.9 mM)
DMSO ：75 mg/mL (177.9 mM)
In vitro(体外研究)
URMC-099 inhibits LPS-induced TNFα release in microglial cells, and HIV-1 Tat-induced release of cytokines in human monocytes. URMC-099 prevents destruction and phagocytosis of cultured neuronal axons by microglia cells. URMC-099 reduces fMLP-induced chemotaxis of wild-type neutrophil in vitro.
In vivo(体内研究)
In mice, URMC-099 shows excellent pharmacokinetic properties and improved CNS penetration. In vivo, URMC-099 (10 mg/kg i.p.) reduces inflammatory cytokine production, protects neuronal architecture, and alters the morphologic and ultrastructural response of microglia to HIV-1 Tat exposure. URMC099 significantly reduces recruitment of neutrophils into the peritoneum by fMLP in wild-type mice.
背景
分子式
C27H27N5
CAS号
1229582-33-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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