VEGF165, Recombinant, Rat (Vascular Endothelial Growth Factor A Isoform 165A, VEGF 165, VEGF165, VEGF165A, VEGFA)

Recombinant, E. coli

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase(flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant rat VEGF is a 38.5kD disulfide-linked homodimeric protein consisting of two 165aa polypeptide chains.

38.5

Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC). The expected ED50 is 4-8ng/ml.

Vascular Endothelial Growth Factor, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A

83785

30021019

P16612