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产品介绍
产品介绍
产品信息
抗原名称
HSP90β
商品描述
VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.
分子量
387.82
纯度
>98%
可溶性
DMSO ：71 mg/mL (183.1 mM)
外观
固体粉末
In vitro(体外研究)
VER-49009 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90 with IC50 of 167 nM, and produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro. VER-49009 causes induction of HSP72 and HSP27 with depletion of client proteins, including C-RAF, B-RAF, and survivin, and PRMT5, which further result in cell cycle arrest and apoptosis. VER-49009 inhibits the cell proliferation, and induces G2 phase arrest in hepatic stellate cell line CFSC cells, which may suggest a rational approach in the prevention of liver fibrosis.
In vivo(体内研究)
In athymic mice, VER-49009 (20 mg/kg, i.v.) shows rapid clearance with values of 0.187 L/h. In an orthotopic human ovarian carcinoma model, VER-49009 (4 mg/kg, i.p.) also induces the depletion of the sensitive HSP90 client protein ERBB2.
背景
别名
CCT0129397
分子式
C19H18ClN3O4
CAS号
940289-57-6；558640-51-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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