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产品介绍
产品介绍
产品信息
抗原名称
HSP90β
商品描述
VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β.
分子量
388.802
纯度
99%
可溶性
200 mM in DMSO and ethanol
In vitro(体外研究)
VER-50589 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90 with IC50 of 143 nM, and produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro. VER-50589 causes induction of HSP72 and HSP27 alongside depletion of client proteins, including C-RAF, B-RAF, and survivin, and the protein arginine methyltransferase PRMT5, which further result in cell cycle arrest and apoptosis.
In vivo(体内研究)
In HCT116 human colon cancer xenografts, VER-50589 (100 mg/kg i.p.) results in a statistically significant reduction of ∼30% in tumor volume and weight, as well as induction of HSP72 and depletion of ERBB2 and C-RAF.
背景
分子式
C19H17ClN2O5
CAS号
747413-08-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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