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产品介绍
产品介绍
产品信息
抗原名称
TLR7
商品描述
GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.
分子量
410.522
纯度
＞98%
可溶性
DMSO: 4.8 mg/mL (Need ultrasonic)
In vitro(体外研究)
GS-9620 potently inhibited viral replication in peripheral blood mononuclear cells(PBMCs), particularly when added 24 to 48 hours prior to HIV infection (EC50= 27 nM). Depletion of pDCs, but not other immune cell subsets from PBMC cultures, suppressed GS-9620 antiviral activity.
In vivo(体内研究)
Short-term oral administration of GS-9620 provides long-term suppression of serum and liver HBV DNA. GS-9620 administration induces production of IFN-α and other cytokines and chemokines, and activates ISGs, natural killer cells, and lymphocyte subsets. Its treatment reduces viral DNA, Serum levels of HB surface antigen, HB e antigen and numbers of HBV antigen-positive hepatocytes while hepatocyte apoptosis increases. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients.
背景
别名
维沙莫德；GS-9620
分子式
C22H30N6O2
CAS号
1228585-88-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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