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Vidofludimus
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产品介绍
产品介绍
产品信息
抗原名称
Human DHODH
商品描述
Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.
分子量
355.36
纯度
>98%
可溶性
DMSO 100 mg/mL warmed (281.4 mM)
Ethanol 1 mg/mL warmed (2.81 mM)
Ethanol 1 mg/mL warmed (2.81 mM)
外观
Powder
In vitro(体外研究)
Vidofludimus causes a concentration dependent inhibition of phytohemagglutinin-stimulated PBMC proliferation via the inhibition of pyrimidine de novo synthesis. Vidofludimus attenuates IL-17 secretion from colonic strips by inhibition of STAT3 and NF-κB activation.
In vivo(体内研究)
In MRLlpr/lpr mice, Vidofludimus (300 mg/kg, p.o.) reduces systemic autoimmunity and improves Lupus Nephritis. In Rats, Vidofludimus (60 mg/kg, p.o.) effectively reduces macroscopic and histological pathology and the numbers of CD3+ T cells. In a rat model of renal transplantation, Vidofludimus (20 mg/kg, p.o.) prolongs survival, paralleled by amelioration of histologic signs of acute rejection.
背景
别名
4sc-101; SC12267,4SC101,4SC 101
分子式
C20H18FNO4
CAS号
717824-30-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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