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Volinanserin
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产品介绍
产品介绍
产品信息
抗原名称
5-HT2 receptor
商品描述
Volinanserin (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma receptors.
分子量
373.46
纯度
98%
可溶性
DMSO : 100 mg/mL (267.8 mM)；
Ethanol : 18 mg/mL (48.2 mM)
Ethanol : 18 mg/mL (48.2 mM)
外观
off-white to light brown powder
In vitro(体外研究)
MDL 100,907 demonstrated low nanomolar or subnanomolar binding in vitro at the 5-HT2A receptor and showed a > 100-fold separation from all other receptors measured. MDL 100,907 had subnanomolar potency as a 5-HT2A antagonist in vitro in reversing 5-HT-stimulated inositol phosphate accumulation in NIH 3T3 cells transfected with the rat 5-HT2A receptor.
In vivo(体内研究)
In mice, MDL 100,907 blocked amphetamine-stimulated locomotion at doses that did not significantly affect apomorphine-stimulated climbing behavior. When administered chronically, MDL 100,907 selectively reduced the number of spontaneously active A10 neurons. In vivo, MDL 100,907 potently inhibited 5-methoxy-N, N-dimethyltryptamine-induced head twitches in mice or 5-hydroxytryptophan-induced head twitches in rats. In vivo, functional tests in mice revealed a > 500-fold separation between doses that produced 5-HT2A antagonism and doses that produced alpha 1-adrenergic or striatal D2 antagonism.
背景
别名
MDL100907；M 100907
分子式
C22H28FNO3
CAS号
139290-65-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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