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VU0463271
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产品介绍
产品介绍
产品信息
商品描述
VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM.
分子量
382.50
纯度
98%
可溶性
DMSO : 25 mg/mL (65.36 mM; Need ultrasonic)
外观
off-white to blue-gray powder
In vitro(体外研究)
VU0463271 is a potent antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels and transporters. It is also found rapidly cleared in vitro.
In vivo(体内研究)
VU0463271 is found to be a moderate-to-high clearance compound in rat (CL=57 mL/min/kg) following intravenous administration (1 mg/kg); the low volume of distribution at steady state (Vss 0.4 L/kg), coupled with moderate-to-high clearance produce a relatively short t1/2 (9 min) in vivo.
背景
别名
VU 0463271
分子式
C19H18N4OS2
CAS号
1391737-01-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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