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产品介绍
产品信息
商品描述
VU661013 is a potent and selective MCL-1 inhibitor.
分子量
712.66
纯度
98%
可溶性
DMSO : ≥ 125 mg/mL (175.40 mM)
In vitro(体外研究)
VU661013 exhibits a Ki of 97±30 pM to human MCL-1 in a TR-FRET assay by displacing a fluorescently labeled peptide derived from the pro-apoptotic protein BAK. However, VU661013 does not significantly inhibit BCL-xL (Ki>40 μM) or BCL-2 (Ki=0.73 μM).
In vivo(体内研究)
VU661013 exhibits a Ki of 97±30 pM to human MCL-1 in a TR-FRET assay by displacing a fluorescently labeled peptide derived from the pro-apoptotic protein BAK. However, VU661013 does not significantly inhibit BCL-xL (Ki>40 μM) or BCL-2 (Ki=0.73 μM).
背景
分子式
C39H39Cl2N5O4
CAS号
2131184-57-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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