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产品介绍
产品介绍
产品信息
商品描述
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.
分子量
462.40
纯度
98%
可溶性
DMSO : 150 mg/mL (324.39 mM; Need ultrasonic)
In vitro(体外研究)
WNK-IN-11 (compound 11) shows IC5050 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.
In vivo(体内研究)
WNK-IN-11 (compound 11) shows IC5050 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.
背景
分子式
C21H21Cl2N5OS
CAS号
2123489-30-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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