全部商品分类
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Wnt3a
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu256 of human Wnt3a.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
同种型
Rabbit IgG
分子量
42
内毒素水平
人, 大鼠
研究领域
癌症,发育生物学与干细胞研究,纤维化,神经科学,
应用
反应种属
Mouse
预测反应种属
Human,Rat,
目标/特异性
Specificity/Sensitivity
Wnt3a (C64F2) Rabbit mAb detects transfected Wnt3a protein in L cells and the conditioned medium from L/Wnt3a cells.
Species Reactivity:
Mouse
敏感性
Transfected Only
背景
背景
The Wnt family includes several secreted glycoproteins that play important roles in animal development (1). There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins (2). Wnt members bind to the Frizzled family of seven-pass transmembrane proteins and activate several signaling pathways (3). The canonical Wnt/β-catenin pathway also requires a coreceptor from the low-density lipoprotein receptor family (4). Aberrant activation of Wnt signaling pathways is involved in several types of cancers (5).
1.Cadigan, K.M. and Nusse, R. (1997) Genes Dev. 11, 3286-3305.
2.Moon, R.T. et al. (1997) Trends Genet. 13, 157-162.
3.Kohn, A.D. and Moon, R.T. (2004) Cell Calcium 38, 439-446.
4.Logan, C.Y. and Nusse, R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810.
5.Giles, R.H. et al. (2003) Biochim. Biophys. Acta. 1653, 1-24.
研究领域
癌症,发育生物学与干细胞研究,纤维化,神经科学,
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
89780
UniProt ID
P56704
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。