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Y-27632 dihydrochloride (1 mg)
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产品介绍
产品信息
商品描述
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
分子量
320.26
化学式
trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
生物活性
Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. Also optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
纯度
≥98% (HPLC)
可溶性
Soluble to 100 mM in water
背景
别名
y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor
结构式
N[C@H](C)[C@@]1([H])CC[C@H](C(NC2=CC=NC=C2)=O)CC1.Cl.Cl
分子式
C14H21N3O.2HCl
CAS号
129830-38-2
制备和贮存
保存方式
Desiccate at RT
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